creatine phosphokinase - définition. Qu'est-ce que creatine phosphokinase
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Qu'est-ce (qui) est creatine phosphokinase - définition

CLASS OF ENZYMES
Creatine phosphokinase; Creatine Phosphokinase; Phosphocreatine kinase; EC 2.7.3.2; ATP:creatine N-phosphotransferase; Creatinine kinase
  • [[Reference ranges for blood tests]], comparing blood content of creatine kinase (shown in orange, to left of ammonia [yellow]) with other constituents.

Creatine transporter defect         
HUMAN DISEASE
Cerebral creatine deficiency syndrome 1
Creatine transporter deficiency (CTD) is an inborn error of creatine metabolism in which creatine is not properly transported to the brain and muscles due to defective creatine transporters. CTD is an X-linked disorder caused by mutation in SLC6A8.
Kreatin         
  • center
  • Proposed creatine kinase/phosphocreatine (CK/PCr) energy shuttle. CRT = creatine transporter; ANT = adenine nucleotide translocator; ATP = adenine triphosphate; ADP = adenine diphosphate; OP = oxidative phosphorylation; mtCK = mitochondrial creatine kinase; G = glycolysis; CK-g = creatine kinase associated with glycolytic enzymes; CK-c = cytosolic creatine kinase; CK-a = creatine kinase associated with subcellular sites of ATP utilization; 1 – 4 sites of CK/ATP interaction.
CHEMICAL COMPOUND
Creatin; Createin; Creatine monohydrate; CE2; Creatine ethyl ester; Creatine Monohydrate; Creatine supplements; Creatine supplement; Creatine gluconate; Creatine Gluconate; (α-methylguanido)acetic acid; Kreatin; Methylguanidinoacetic acid; N-amidinosarcosine; Creatine ethyl ester malate; User:Healthycare/Creatine Ethyl Ester Malate; Creatine Ethyl Ester Hydrochloride; User:Healthycare/Creatine Ethyl Ester Hydrochloride; Dicreatine Malate; User:Healthycare/DiCreatine Malate; Creatine ester; Cre-ester; Creatine hydrochloride; CrHCl; Creatine HCl; Cosmocair C 100; Krebiozon; Pyrolysate; Creatine deficiency; Kreatine; H2N)(HN)CN(CH3)CH2CO2H
·noun ·see Creatin.
Creatin         
  • center
  • Proposed creatine kinase/phosphocreatine (CK/PCr) energy shuttle. CRT = creatine transporter; ANT = adenine nucleotide translocator; ATP = adenine triphosphate; ADP = adenine diphosphate; OP = oxidative phosphorylation; mtCK = mitochondrial creatine kinase; G = glycolysis; CK-g = creatine kinase associated with glycolytic enzymes; CK-c = cytosolic creatine kinase; CK-a = creatine kinase associated with subcellular sites of ATP utilization; 1 – 4 sites of CK/ATP interaction.
CHEMICAL COMPOUND
Creatin; Createin; Creatine monohydrate; CE2; Creatine ethyl ester; Creatine Monohydrate; Creatine supplements; Creatine supplement; Creatine gluconate; Creatine Gluconate; (α-methylguanido)acetic acid; Kreatin; Methylguanidinoacetic acid; N-amidinosarcosine; Creatine ethyl ester malate; User:Healthycare/Creatine Ethyl Ester Malate; Creatine Ethyl Ester Hydrochloride; User:Healthycare/Creatine Ethyl Ester Hydrochloride; Dicreatine Malate; User:Healthycare/DiCreatine Malate; Creatine ester; Cre-ester; Creatine hydrochloride; CrHCl; Creatine HCl; Cosmocair C 100; Krebiozon; Pyrolysate; Creatine deficiency; Kreatine; H2N)(HN)CN(CH3)CH2CO2H
·noun A white, crystalline, nitrogenous substance found abundantly in muscle tissue.

Wikipédia

Creatine kinase

Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC 2.7.3.2) expressed by various tissues and cell types. CK catalyses the conversion of creatine and uses adenosine triphosphate (ATP) to create phosphocreatine (PCr) and adenosine diphosphate (ADP). This CK enzyme reaction is reversible and thus ATP can be generated from PCr and ADP.

In tissues and cells that consume ATP rapidly, especially skeletal muscle, but also brain, photoreceptor cells of the retina, hair cells of the inner ear, spermatozoa and smooth muscle, PCr serves as an energy reservoir for the rapid buffering and regeneration of ATP in situ, as well as for intracellular energy transport by the PCr shuttle or circuit. Thus creatine kinase is an important enzyme in such tissues.

Clinically, creatine kinase is assayed in blood tests as a marker of damage of CK-rich tissue such as in myocardial infarction (heart attack), rhabdomyolysis (severe muscle breakdown), muscular dystrophy, autoimmune myositides, and acute kidney injury.